Detailed information of TA system TA208670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1403969..1404498
• Replicon: chromosome
• Accession: NZ_CP077928
• Organism: Staphylococcus aureus strain 196

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: KU511_RS07065
• Protein ID: WP_001103939.1
• Coordinates: 1403969..1404286 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: KU511_RS07070
• Protein ID: WP_001058494.1
• Coordinates: 1404289..1404498 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU511_RS07040 (1399975)	1399975..1400616	-	642	WP_001019808.1	hypothetical protein	-
KU511_RS07045 (1400613)	1400613..1400897	-	285	WP_000998185.1	hypothetical protein	-
KU511_RS07050 (1400899)	1400899..1401261	-	363	WP_001039170.1	hypothetical protein	-
KU511_RS07055 (1401562)	1401562..1403019	-	1458	WP_000390453.1	virulence-associated E family protein	-
KU511_RS07060 (1403036)	1403036..1403905	-	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
KU511_RS07065 (1403969)	1403969..1404286	-	318	WP_001103939.1	DUF1474 family protein	Toxin
KU511_RS07070 (1404289)	1404289..1404498	-	210	WP_001058494.1	hypothetical protein	Antitoxin
KU511_RS07075 (1404491)	1404491..1404637	-	147	WP_000784885.1	hypothetical protein	-
KU511_RS07080 (1404649)	1404649..1404867	-	219	WP_000163544.1	helix-turn-helix transcriptional regulator	-
KU511_RS07085 (1404903)	1404903..1405106	-	204	WP_001045296.1	transcriptional regulator	-
KU511_RS07090 (1405242)	1405242..1406045	+	804	WP_000358990.1	helix-turn-helix transcriptional regulator	-
KU511_RS07095 (1406035)	1406035..1407141	+	1107	WP_000149511.1	tyrosine-type recombinase/integrase	-
KU511_RS07100 (1407648)	1407648..1407851	-	204	WP_017804629.1	hypothetical protein	-
KU511_RS07105 (1408290)	1408290..1408904	-	615	WP_029550584.1	hypothetical protein	-
KU511_RS07110 (1408901)	1408901..1409077	-	177	WP_168240022.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / sell / sec	1371764..1450294	78530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T208670 WP_001103939.1 NZ_CP077928:c1404286-1403969 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T208670 NZ_CP103704:1808503-1808754 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT208670 WP_001058494.1 NZ_CP077928:c1404498-1404289 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT208670 NZ_CP103704:1808751-1809005 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59