Detailed information of TA system TA208669

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1374686..1375163
• Replicon: chromosome
• Accession: NZ_CP077928
• Organism: Staphylococcus aureus strain 196

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU511_RS06900
• Protein ID: WP_000052076.1
• Coordinates: 1374975..1375163 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KU511_RS06895
• Protein ID: WP_225798476.1
• Coordinates: 1374686..1374946 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU511_RS06860 (1370080)	1370080..1370796	-	717	WP_000150033.1	type I 3-dehydroquinate dehydratase	-
KU511_RS06865 (1370944)	1370944..1371366	+	423	WP_000974451.1	organic hydroperoxide resistance protein	-
KU511_RS06870 (1371764)	1371764..1372258	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KU511_RS06875 (1372414)	1372414..1373031	+	618	WP_000255550.1	LysE/ArgO family amino acid transporter	-
KU511_RS06880 (1373104)	1373104..1373685	-	582	WP_001140696.1	histidine phosphatase family protein	-
KU511_RS06885 (1373909)	1373909..1374145	+	237	WP_000368687.1	hypothetical protein	-
KU511_RS06890 (1374142)	1374142..1374345	-	204	WP_000145160.1	sterile alpha motif-like domain-containing protein	-
KU511_RS06895 (1374686)	1374686..1374946	+	261	WP_225798476.1	hypothetical protein	Antitoxin
KU511_RS06900 (1374975)	1374975..1375163	+	189	WP_000052076.1	hypothetical protein	Toxin
KU511_RS06905 (1375351)	1375351..1375920	+	570	WP_001106662.1	lipoprotein N-acylation protein LnsA	-
KU511_RS06910 (1376008)	1376008..1376280	+	273	WP_001004400.1	hypothetical protein	-
KU511_RS06915 (1376353)	1376353..1376571	+	219	WP_000005884.1	hypothetical protein	-
KU511_RS06920 (1377068)	1377068..1377268	-	201	WP_001059082.1	cold-shock protein	-
KU511_RS06925 (1377628)	1377628..1378314	-	687	WP_001622483.1	thermonuclease family protein	-
KU511_RS06930 (1378655)	1378655..1379176	-	522	WP_000824479.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / sell / sec	1371764..1450294	78530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-109)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208669 WP_000052076.1 NZ_CP077928:1374975-1375163 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208669 NZ_CP103704:1034290-1034625 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGATTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9950.13 Da
• Isoelectric Point: 4.0624

>AT208669 WP_225798476.1 NZ_CP077928:1374686-1374946 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVPFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208669 NZ_CP103704:1034042-1034290 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18