Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 156556..157070 Replicon chromosome
Accession NZ_CP077928
Organism Staphylococcus aureus strain 196

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU511_RS00840 Protein ID WP_000581795.1
Coordinates 156861..157070 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag KU511_RS00835 Protein ID WP_000138930.1
Coordinates 156556..156849 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU511_RS00815 (152082) 152082..152723 + 642 WP_000483162.1 thiamine phosphate synthase -
KU511_RS00820 (152809) 152809..153681 + 873 WP_000725802.1 membrane protein insertase YidC -
KU511_RS00825 (154231) 154231..154878 - 648 WP_225798424.1 HD domain-containing protein -
KU511_RS00830 (154906) 154906..156390 - 1485 WP_000571562.1 cardiolipin synthase -
KU511_RS00835 (156556) 156556..156849 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU511_RS00840 (156861) 156861..157070 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU511_RS00845 (157198) 157198..157335 + 138 WP_000828354.1 Lmo0850 family protein -
KU511_RS00850 (157599) 157599..158801 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU511_RS00855 (159119) 159119..160189 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU511_RS00860 (160204) 160204..161562 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208662 WP_000581795.1 NZ_CP077928:156861-157070 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208662 NZ_CP103699:c5256781-5256398 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT208662 WP_000138930.1 NZ_CP077928:156556-156849 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208662 NZ_CP103699:c5257023-5256781 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References