Detailed information of TA system TA208660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2467292..2467821
• Replicon: chromosome
• Accession: NZ_CP077926
• Organism: Staphylococcus aureus strain 197

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: KU504_RS12115
• Protein ID: WP_001103939.1
• Coordinates: 2467292..2467609 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: KU504_RS12120
• Protein ID: WP_001058494.1
• Coordinates: 2467612..2467821 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU504_RS13820 (2462917)	2462917..2463051	-	135	WP_256094151.1	hypothetical protein	-
KU504_RS12090 (2463298)	2463298..2463939	-	642	WP_001019808.1	hypothetical protein	-
KU504_RS12095 (2463936)	2463936..2464220	-	285	WP_000998185.1	hypothetical protein	-
KU504_RS12100 (2464222)	2464222..2464584	-	363	WP_001039170.1	hypothetical protein	-
KU504_RS12105 (2464885)	2464885..2466342	-	1458	WP_000390453.1	virulence-associated E family protein	-
KU504_RS12110 (2466359)	2466359..2467228	-	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
KU504_RS12115 (2467292)	2467292..2467609	-	318	WP_001103939.1	DUF1474 family protein	Toxin
KU504_RS12120 (2467612)	2467612..2467821	-	210	WP_001058494.1	hypothetical protein	Antitoxin
KU504_RS12125 (2467814)	2467814..2467960	-	147	WP_000784885.1	hypothetical protein	-
KU504_RS12130 (2467972)	2467972..2468190	-	219	WP_000163544.1	helix-turn-helix transcriptional regulator	-
KU504_RS12135 (2468226)	2468226..2468429	-	204	WP_001045296.1	transcriptional regulator	-
KU504_RS12140 (2468565)	2468565..2469368	+	804	WP_000358990.1	helix-turn-helix transcriptional regulator	-
KU504_RS12145 (2469358)	2469358..2470464	+	1107	WP_000149511.1	tyrosine-type recombinase/integrase	-
KU504_RS12150 (2470971)	2470971..2471174	-	204	WP_017804629.1	hypothetical protein	-
KU504_RS12155 (2471613)	2471613..2472227	-	615	WP_029550584.1	hypothetical protein	-
KU504_RS12160 (2472224)	2472224..2472400	-	177	WP_168240022.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / sell / sec	2435090..2516987	81897

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T208660 WP_001103939.1 NZ_CP077926:c2467609-2467292 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T208660 NZ_CP103699:c4772252-4771968 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT208660 WP_001058494.1 NZ_CP077926:c2467821-2467612 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT208660 NZ_CP103699:c4772484-4772242 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59