Detailed information of TA system TA208659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2438012..2438489
• Replicon: chromosome
• Accession: NZ_CP077926
• Organism: Staphylococcus aureus strain 197

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU504_RS11950
• Protein ID: WP_000052076.1
• Coordinates: 2438301..2438489 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KU504_RS11945
• Protein ID: WP_225798476.1
• Coordinates: 2438012..2438272 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU504_RS11910 (2433406)	2433406..2434122	-	717	WP_000150033.1	type I 3-dehydroquinate dehydratase	-
KU504_RS11915 (2434270)	2434270..2434692	+	423	WP_000974451.1	organic hydroperoxide resistance protein	-
KU504_RS11920 (2435090)	2435090..2435584	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KU504_RS11925 (2435740)	2435740..2436357	+	618	WP_000255550.1	LysE/ArgO family amino acid transporter	-
KU504_RS11930 (2436430)	2436430..2437011	-	582	WP_001140696.1	histidine phosphatase family protein	-
KU504_RS11935 (2437235)	2437235..2437471	+	237	WP_000368687.1	hypothetical protein	-
KU504_RS11940 (2437468)	2437468..2437671	-	204	WP_000145160.1	sterile alpha motif-like domain-containing protein	-
KU504_RS11945 (2438012)	2438012..2438272	+	261	WP_225798476.1	hypothetical protein	Antitoxin
KU504_RS11950 (2438301)	2438301..2438489	+	189	WP_000052076.1	hypothetical protein	Toxin
KU504_RS11955 (2438677)	2438677..2439246	+	570	WP_001106662.1	lipoprotein N-acylation protein LnsA	-
KU504_RS11960 (2439334)	2439334..2439606	+	273	WP_001004400.1	hypothetical protein	-
KU504_RS11965 (2439679)	2439679..2439897	+	219	WP_000005884.1	hypothetical protein	-
KU504_RS11970 (2440394)	2440394..2440594	-	201	WP_001059082.1	cold-shock protein	-
KU504_RS11975 (2440951)	2440951..2441637	-	687	WP_001622483.1	thermonuclease family protein	-
KU504_RS11980 (2441978)	2441978..2442499	-	522	WP_000824479.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / sell / sec	2435090..2516987	81897

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (13-112)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208659 WP_000052076.1 NZ_CP077926:2438301-2438489 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208659 NZ_CP103699:c4679581-4679240 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9950.13 Da
• Isoelectric Point: 4.0624

>AT208659 WP_225798476.1 NZ_CP077926:2438012-2438272 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVPFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208659 NZ_CP103699:c4679943-4679602 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18