Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1219881..1220395 Replicon chromosome
Accession NZ_CP077926
Organism Staphylococcus aureus strain 197

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU504_RS05880 Protein ID WP_000581795.1
Coordinates 1220186..1220395 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag KU504_RS05875 Protein ID WP_000138930.1
Coordinates 1219881..1220174 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU504_RS05855 (1215407) 1215407..1216048 + 642 WP_000483162.1 thiamine phosphate synthase -
KU504_RS05860 (1216134) 1216134..1217006 + 873 WP_000725802.1 membrane protein insertase YidC -
KU504_RS05865 (1217556) 1217556..1218203 - 648 WP_225798424.1 HD domain-containing protein -
KU504_RS05870 (1218231) 1218231..1219715 - 1485 WP_000571562.1 cardiolipin synthase -
KU504_RS05875 (1219881) 1219881..1220174 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU504_RS05880 (1220186) 1220186..1220395 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU504_RS05885 (1220523) 1220523..1220660 + 138 WP_000828354.1 Lmo0850 family protein -
KU504_RS05890 (1220924) 1220924..1222126 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU504_RS05895 (1222444) 1222444..1223514 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU504_RS05900 (1223529) 1223529..1224887 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208652 WP_000581795.1 NZ_CP077926:1220186-1220395 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208652 NZ_CP103699:349412-349759 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT208652 WP_000138930.1 NZ_CP077926:1219881-1220174 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208652 NZ_CP103699:349759-350058 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References