Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2206759..2207273 Replicon chromosome
Accession NZ_CP077925
Organism Staphylococcus aureus strain 198

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU531_RS10880 Protein ID WP_000581795.1
Coordinates 2206759..2206968 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag KU531_RS10885 Protein ID WP_000138930.1
Coordinates 2206980..2207273 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU531_RS10860 (2202267) 2202267..2203625 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU531_RS10865 (2203640) 2203640..2204710 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU531_RS10870 (2205028) 2205028..2206230 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU531_RS10875 (2206494) 2206494..2206631 - 138 WP_000828354.1 Lmo0850 family protein -
KU531_RS10880 (2206759) 2206759..2206968 - 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU531_RS10885 (2206980) 2206980..2207273 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU531_RS10890 (2207439) 2207439..2208923 + 1485 WP_000571562.1 cardiolipin synthase -
KU531_RS10895 (2208951) 2208951..2209598 + 648 WP_225798424.1 HD domain-containing protein -
KU531_RS10900 (2210148) 2210148..2211020 - 873 WP_000725802.1 membrane protein insertase YidC -
KU531_RS10905 (2211106) 2211106..2211747 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208651 WP_000581795.1 NZ_CP077925:c2206968-2206759 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208651 NZ_CP103699:323451-323819 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT208651 WP_000138930.1 NZ_CP077925:c2207273-2206980 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208651 NZ_CP103699:323233-323454 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References