Detailed information of TA system TA208647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2004971..2005747
• Replicon: chromosome
• Accession: NZ_CP077925
• Organism: Staphylococcus aureus strain 198

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KU531_RS09710
• Protein ID: WP_000031109.1
• Coordinates: 2004971..2005123 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KU531_RS09715
• Protein ID: WP_001251224.1
• Coordinates: 2005148..2005747 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU531_RS09695 (2000892)	2000892..2001713	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
KU531_RS09700 (2002170)	2002170..2003555	-	1386	WP_000116239.1	class II fumarate hydratase	-
KU531_RS09705 (2003751)	2003751..2004146	-	396	WP_000901019.1	hypothetical protein	-
KU531_RS09710 (2004971)	2004971..2005123	-	153	WP_000031109.1	SAS053 family protein	Toxin
KU531_RS09715 (2005148)	2005148..2005747	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KU531_RS09720 (2005906)	2005906..2006376	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KU531_RS09725 (2006381)	2006381..2007508	-	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
KU531_RS09730 (2007659)	2007659..2008381	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KU531_RS09735 (2008374)	2008374..2009831	-	1458	WP_225798433.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T208647 WP_000031109.1 NZ_CP077925:c2005123-2004971 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T208647 NZ_CP103697:4573346-4573714 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT208647 WP_001251224.1 NZ_CP077925:c2005747-2005148 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT208647 NZ_CP103697:4573128-4573349 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAACTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: W8U4V4