Detailed information of TA system TA208646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 988666..989143
• Replicon: chromosome
• Accession: NZ_CP077925
• Organism: Staphylococcus aureus strain 198

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU531_RS04810
• Protein ID: WP_000052076.1
• Coordinates: 988666..988854 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KU531_RS04815
• Protein ID: WP_225798476.1
• Coordinates: 988883..989143 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU531_RS04780 (984656)	984656..985177	+	522	WP_000824479.1	hypothetical protein	-
KU531_RS04785 (985518)	985518..986204	+	687	WP_001622483.1	thermonuclease family protein	-
KU531_RS04790 (986561)	986561..986761	+	201	WP_001059082.1	cold-shock protein	-
KU531_RS04795 (987258)	987258..987476	-	219	WP_000005884.1	hypothetical protein	-
KU531_RS04800 (987549)	987549..987821	-	273	WP_001004400.1	hypothetical protein	-
KU531_RS04805 (987909)	987909..988478	-	570	WP_001106662.1	lipoprotein N-acylation protein LnsA	-
KU531_RS04810 (988666)	988666..988854	-	189	WP_000052076.1	hypothetical protein	Toxin
KU531_RS04815 (988883)	988883..989143	-	261	WP_225798476.1	hypothetical protein	Antitoxin
KU531_RS04820 (989484)	989484..989687	+	204	WP_000145160.1	sterile alpha motif-like domain-containing protein	-
KU531_RS04825 (989684)	989684..989920	-	237	WP_000368687.1	hypothetical protein	-
KU531_RS04830 (990144)	990144..990725	+	582	WP_001140696.1	histidine phosphatase family protein	-
KU531_RS04835 (990798)	990798..991415	-	618	WP_000255550.1	LysE/ArgO family amino acid transporter	-
KU531_RS04840 (991571)	991571..992065	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KU531_RS04845 (992463)	992463..992885	-	423	WP_000974451.1	organic hydroperoxide resistance protein	-
KU531_RS04850 (993033)	993033..993749	+	717	WP_000150033.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (45-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208646 WP_000052076.1 NZ_CP077925:c988854-988666 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208646 NZ_CP103697:4370382-4370867 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9950.13 Da
• Isoelectric Point: 4.0624

>AT208646 WP_225798476.1 NZ_CP077925:c989143-988883 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVPFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208646 NZ_CP103697:4370128-4370394 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18