Detailed information of TA system TA208643

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1812520..1812996
• Replicon: chromosome
• Accession: NZ_CP077924
• Organism: Staphylococcus aureus strain 200

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU536_RS09175
• Protein ID: WP_000052076.1
• Coordinates: 1812808..1812996 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KU536_RS09170
• Protein ID: WP_031892543.1
• Coordinates: 1812520..1812780 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU536_RS09135 (1807918)	1807918..1808634	-	717	WP_000150026.1	type I 3-dehydroquinate dehydratase	-
KU536_RS09140 (1808782)	1808782..1809204	+	423	WP_000974452.1	organic hydroperoxide resistance protein	-
KU536_RS09145 (1809603)	1809603..1810097	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
KU536_RS09150 (1810246)	1810246..1810863	+	618	WP_000255562.1	LysE/ArgO family amino acid transporter	-
KU536_RS09155 (1810936)	1810936..1811517	-	582	WP_001140696.1	histidine phosphatase family protein	-
KU536_RS09160 (1811742)	1811742..1811978	+	237	WP_000368687.1	hypothetical protein	-
KU536_RS09165 (1811975)	1811975..1812178	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KU536_RS09170 (1812520)	1812520..1812780	+	261	WP_031892543.1	hypothetical protein	Antitoxin
KU536_RS09175 (1812808)	1812808..1812996	+	189	WP_000052076.1	hypothetical protein	Toxin
KU536_RS09180 (1813184)	1813184..1813753	+	570	WP_001106655.1	lipoprotein N-acylation protein LnsA	-
KU536_RS09185 (1813841)	1813841..1814125	+	285	WP_001004403.1	hypothetical protein	-
KU536_RS09190 (1814186)	1814186..1814404	+	219	WP_000005881.1	hypothetical protein	-
KU536_RS09195 (1814901)	1814901..1815101	-	201	WP_001059082.1	cold-shock protein	-
KU536_RS09200 (1815458)	1815458..1816144	-	687	WP_001574556.1	thermonuclease family protein	-
KU536_RS09205 (1816485)	1816485..1816967	-	483	WP_000824490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208643 WP_000052076.1 NZ_CP077924:1812808-1812996 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208643 NZ_CP103697:c3555013-3554729 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTTAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9970.12 Da
• Isoelectric Point: 4.0624

>AT208643 WP_031892543.1 NZ_CP077924:1812520-1812780 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPSIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208643 NZ_CP103697:c3555245-3555003 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18