Detailed information of TA system TA208626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1759863..1760339
• Replicon: chromosome
• Accession: NZ_CP077923
• Organism: Staphylococcus aureus strain 201

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU534_RS08910
• Protein ID: WP_000052076.1
• Coordinates: 1760151..1760339 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KU534_RS08905
• Protein ID: WP_031892543.1
• Coordinates: 1759863..1760123 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU534_RS08870 (1755261)	1755261..1755977	-	717	WP_000150026.1	type I 3-dehydroquinate dehydratase	-
KU534_RS08875 (1756125)	1756125..1756547	+	423	WP_000974452.1	organic hydroperoxide resistance protein	-
KU534_RS08880 (1756946)	1756946..1757440	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
KU534_RS08885 (1757589)	1757589..1758206	+	618	WP_000255562.1	LysE/ArgO family amino acid transporter	-
KU534_RS08890 (1758279)	1758279..1758860	-	582	WP_001140696.1	histidine phosphatase family protein	-
KU534_RS08895 (1759085)	1759085..1759321	+	237	WP_000368687.1	hypothetical protein	-
KU534_RS08900 (1759318)	1759318..1759521	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KU534_RS08905 (1759863)	1759863..1760123	+	261	WP_031892543.1	hypothetical protein	Antitoxin
KU534_RS08910 (1760151)	1760151..1760339	+	189	WP_000052076.1	hypothetical protein	Toxin
KU534_RS08915 (1760527)	1760527..1761096	+	570	WP_001106655.1	lipoprotein N-acylation protein LnsA	-
KU534_RS08920 (1761184)	1761184..1761468	+	285	WP_001004403.1	hypothetical protein	-
KU534_RS08925 (1761529)	1761529..1761747	+	219	WP_000005881.1	hypothetical protein	-
KU534_RS08930 (1762244)	1762244..1762444	-	201	WP_001059082.1	cold-shock protein	-
KU534_RS08935 (1762801)	1762801..1763487	-	687	WP_001574556.1	thermonuclease family protein	-
KU534_RS08940 (1763828)	1763828..1764310	-	483	WP_000824490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208626 WP_000052076.1 NZ_CP077923:1760151-1760339 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208626 NZ_CP103694:1807107-1807361 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAATCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9970.12 Da
• Isoelectric Point: 4.0624

>AT208626 WP_031892543.1 NZ_CP077923:1759863-1760123 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPSIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208626 NZ_CP103694:1806859-1807110 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18