Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1492198..1492712 Replicon chromosome
Accession NZ_CP077922
Organism Staphylococcus aureus strain 202

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU538_RS07440 Protein ID WP_000581792.1
Coordinates 1492198..1492407 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU538_RS07445 Protein ID WP_000138932.1
Coordinates 1492419..1492712 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU538_RS07420 (1487709) 1487709..1489064 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU538_RS07425 (1489079) 1489079..1490149 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU538_RS07430 (1490467) 1490467..1491669 + 1203 WP_020978293.1 FtsW/RodA/SpoVE family cell cycle protein -
KU538_RS07435 (1491933) 1491933..1492070 - 138 WP_000828354.1 Lmo0850 family protein -
KU538_RS07440 (1492198) 1492198..1492407 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU538_RS07445 (1492419) 1492419..1492712 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU538_RS07450 (1492878) 1492878..1494362 + 1485 WP_000571550.1 cardiolipin synthase -
KU538_RS07455 (1494390) 1494390..1495037 + 648 WP_001187614.1 HD domain-containing protein -
KU538_RS07460 (1495594) 1495594..1495656 + 63 Protein_1441 hypothetical protein -
KU538_RS07465 (1495634) 1495634..1496949 - 1316 Protein_1442 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208606 WP_000581792.1 NZ_CP077922:c1492407-1492198 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208606 NZ_CP103687:323453-323821 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208606 WP_000138932.1 NZ_CP077922:c1492712-1492419 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208606 NZ_CP103687:323235-323456 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References