Detailed information of TA system TA208605

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1472461..1472990
• Replicon: chromosome
• Accession: NZ_CP077922
• Organism: Staphylococcus aureus strain 202

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KU538_RS07350
• Protein ID: WP_000621175.1
• Coordinates: 1472461..1472823 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: KU538_RS07355
• Protein ID: WP_000948331.1
• Coordinates: 1472820..1472990 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU538_RS07330 (1469440)	1469440..1470210	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
KU538_RS07335 (1470185)	1470185..1470664	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
KU538_RS07340 (1470666)	1470666..1470992	-	327	WP_001052491.1	anti-sigma factor antagonist	-
KU538_RS07345 (1471111)	1471111..1472112	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
KU538_RS07350 (1472461)	1472461..1472823	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KU538_RS07355 (1472820)	1472820..1472990	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
KU538_RS07360 (1473075)	1473075..1474223	-	1149	WP_001281139.1	alanine racemase	-
KU538_RS07365 (1474289)	1474289..1474648	-	360	WP_000581197.1	holo-ACP synthase	-
KU538_RS07370 (1474652)	1474652..1475143	-	492	WP_001286980.1	PH domain-containing protein	-
KU538_RS07375 (1475136)	1475136..1476713	-	1578	WP_001294650.1	PH domain-containing protein	-
KU538_RS07380 (1476706)	1476706..1477185	-	480	WP_001287081.1	hypothetical protein	-
KU538_RS07385 (1477394)	1477394..1477954	-	561	WP_001092419.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T208605 WP_000621175.1 NZ_CP077922:c1472823-1472461 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T208605 NZ_CP103685:c58386-57970 [Enterobacter hormaechei]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT208605 WP_000948331.1 NZ_CP077922:c1472990-1472820 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT208605 NZ_CP103685:c58613-58383 [Enterobacter hormaechei]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGGCCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1