Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 258905..259381 Replicon chromosome
Accession NZ_CP077922
Organism Staphylococcus aureus strain 202

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU538_RS01245 Protein ID WP_000052076.1
Coordinates 258905..259093 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID -
Locus tag KU538_RS01250 Protein ID WP_031892543.1
Coordinates 259121..259381 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU538_RS01215 (254934) 254934..255416 + 483 WP_000824490.1 hypothetical protein -
KU538_RS01220 (255757) 255757..256443 + 687 WP_001574556.1 thermonuclease family protein -
KU538_RS01225 (256800) 256800..257000 + 201 WP_001059082.1 cold-shock protein -
KU538_RS01230 (257497) 257497..257715 - 219 WP_000005881.1 hypothetical protein -
KU538_RS01235 (257776) 257776..258060 - 285 WP_001004403.1 hypothetical protein -
KU538_RS01240 (258148) 258148..258717 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
KU538_RS01245 (258905) 258905..259093 - 189 WP_000052076.1 hypothetical protein Toxin
KU538_RS01250 (259121) 259121..259381 - 261 WP_031892543.1 hypothetical protein Antitoxin
KU538_RS01255 (259723) 259723..259926 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU538_RS01260 (259923) 259923..260159 - 237 WP_000368687.1 hypothetical protein -
KU538_RS01265 (260384) 260384..260965 + 582 WP_001140696.1 histidine phosphatase family protein -
KU538_RS01270 (261038) 261038..261655 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
KU538_RS01275 (261804) 261804..262298 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
KU538_RS01280 (262697) 262697..263119 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
KU538_RS01285 (263267) 263267..263983 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208596 WP_000052076.1 NZ_CP077922:c259093-258905 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208596 NZ_CP103683:c2689604-2689501 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9970.12 Da        Isoelectric Point: 4.0624

>AT208596 WP_031892543.1 NZ_CP077922:c259381-259121 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPSIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208596 NZ_CP103683:2689499-2689697 [Enterobacter hormaechei]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCAAAAGTGGTCTG
AAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure

References