Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2578052..2578566 Replicon chromosome
Accession NZ_CP077921
Organism Staphylococcus aureus strain 276

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU530_RS12665 Protein ID WP_000581792.1
Coordinates 2578357..2578566 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU530_RS12660 Protein ID WP_000138932.1
Coordinates 2578052..2578345 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU530_RS12640 (KU530_12590) 2573401..2574042 + 642 WP_000483153.1 thiamine phosphate synthase -
KU530_RS12645 (KU530_12595) 2574128..2575000 + 873 WP_000725802.1 membrane protein insertase YidC -
KU530_RS12650 (KU530_12600) 2575727..2576374 - 648 WP_001187634.1 HD domain-containing protein -
KU530_RS12655 (KU530_12605) 2576402..2577886 - 1485 WP_000571549.1 cardiolipin synthase -
KU530_RS12660 (KU530_12610) 2578052..2578345 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU530_RS12665 (KU530_12615) 2578357..2578566 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU530_RS12670 (KU530_12620) 2578694..2578831 + 138 WP_000828354.1 Lmo0850 family protein -
KU530_RS12675 (KU530_12625) 2579095..2580297 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU530_RS12680 (KU530_12630) 2580615..2581685 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KU530_RS12685 (KU530_12635) 2581700..2583058 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208594 WP_000581792.1 NZ_CP077921:2578357-2578566 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208594 NZ_CP103683:1757908-1758429 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGGTACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGTTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATCGAACGACTGTTTGAGCAGTCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208594 WP_000138932.1 NZ_CP077921:2578052-2578345 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208594 NZ_CP103683:1757632-1757901 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References