Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1115535..1116012 | Replicon | chromosome |
| Accession | NZ_CP077921 | ||
| Organism | Staphylococcus aureus strain 276 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | KU530_RS05550 | Protein ID | WP_000052076.1 |
| Coordinates | 1115824..1116012 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | KU530_RS05545 | Protein ID | WP_001059690.1 |
| Coordinates | 1115535..1115795 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU530_RS05515 (KU530_05490) | 1110694..1111188 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| KU530_RS05520 (KU530_05495) | 1111528..1113174 | + | 1647 | WP_000277718.1 | IS1182 family transposase | - |
| KU530_RS05525 (KU530_05500) | 1113262..1113879 | + | 618 | WP_000255557.1 | LysE/ArgO family amino acid transporter | - |
| KU530_RS05530 (KU530_05505) | 1113952..1114533 | - | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| KU530_RS05535 (KU530_05510) | 1114758..1114994 | + | 237 | WP_000368687.1 | hypothetical protein | - |
| KU530_RS05540 (KU530_05515) | 1114991..1115194 | - | 204 | WP_000145164.1 | sterile alpha motif-like domain-containing protein | - |
| KU530_RS05545 (KU530_05520) | 1115535..1115795 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| KU530_RS05550 (KU530_05525) | 1115824..1116012 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| KU530_RS05555 (KU530_05530) | 1116200..1116769 | + | 570 | Protein_1069 | hypothetical protein | - |
| KU530_RS05560 (KU530_05535) | 1116857..1117141 | + | 285 | WP_001004401.1 | hypothetical protein | - |
| KU530_RS05565 (KU530_05540) | 1117203..1117421 | + | 219 | WP_000005886.1 | hypothetical protein | - |
| KU530_RS05570 (KU530_05545) | 1117917..1118117 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| KU530_RS05575 (KU530_05550) | 1118474..1119160 | - | 687 | WP_001641381.1 | thermonuclease family protein | - |
| KU530_RS05580 (KU530_05555) | 1119501..1119971 | - | 471 | WP_000824467.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 1110694..1129904 | 19210 | |
| - | flank | IS/Tn | - | - | 1111528..1113174 | 1646 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T208585 WP_000052076.1 NZ_CP077921:1115824-1116012 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T208585 NZ_CP103679:c4008214-4007837 [Enterobacter hormaechei]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT208585 WP_001059690.1 NZ_CP077921:1115535-1115795 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT208585 NZ_CP103679:c4008624-4008265 [Enterobacter hormaechei]
TTGTCGAATGAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTACAGGCGGGCAACCGTCTGCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACG
CTGATTTACGGTATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAAT
CCCTGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCATAA
TTGTCGAATGAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTACAGGCGGGCAACCGTCTGCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACG
CTGATTTACGGTATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAAT
CCCTGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |