Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1880181..1880695 Replicon chromosome
Accession NZ_CP077920
Organism Staphylococcus aureus strain 277

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag KU525_RS09270 Protein ID WP_000581793.1
Coordinates 1880486..1880695 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU525_RS09265 Protein ID WP_000138932.1
Coordinates 1880181..1880474 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU525_RS09245 (1875545) 1875545..1876186 + 642 WP_000483164.1 thiamine phosphate synthase -
KU525_RS09250 (1876272) 1876272..1877144 + 873 WP_000725802.1 membrane protein insertase YidC -
KU525_RS09255 (1877856) 1877856..1878503 - 648 WP_001187627.1 HD domain-containing protein -
KU525_RS09260 (1878531) 1878531..1880015 - 1485 WP_000571552.1 cardiolipin synthase -
KU525_RS09265 (1880181) 1880181..1880474 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU525_RS09270 (1880486) 1880486..1880695 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
KU525_RS09275 (1880823) 1880823..1880960 + 138 WP_000828354.1 Lmo0850 family protein -
KU525_RS09280 (1881223) 1881223..1882425 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU525_RS09285 (1882743) 1882743..1883813 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KU525_RS09290 (1883828) 1883828..1885186 + 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T208581 WP_000581793.1 NZ_CP077920:1880486-1880695 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T208581 NZ_CP103679:c2689604-2689501 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208581 WP_000138932.1 NZ_CP077920:1880181-1880474 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208581 NZ_CP103679:2689499-2689697 [Enterobacter hormaechei]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCAAAAGTGGTCTG
AAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References