Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1040077..1040554 Replicon chromosome
Accession NZ_CP077919
Organism Staphylococcus aureus strain 278

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU514_RS05350 Protein ID WP_000052076.1
Coordinates 1040366..1040554 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU514_RS05345 Protein ID WP_001059690.1
Coordinates 1040077..1040337 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU514_RS05315 (KU514_05280) 1035236..1035730 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU514_RS05320 (KU514_05285) 1036070..1037716 + 1647 WP_000277718.1 IS1182 family transposase -
KU514_RS05325 (KU514_05290) 1037804..1038421 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
KU514_RS05330 (KU514_05295) 1038494..1039075 - 582 WP_001140693.1 histidine phosphatase family protein -
KU514_RS05335 (KU514_05300) 1039300..1039536 + 237 WP_000368687.1 hypothetical protein -
KU514_RS05340 (KU514_05305) 1039533..1039736 - 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
KU514_RS05345 (KU514_05310) 1040077..1040337 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU514_RS05350 (KU514_05315) 1040366..1040554 + 189 WP_000052076.1 hypothetical protein Toxin
KU514_RS05355 (KU514_05320) 1040742..1041311 + 570 Protein_1004 hypothetical protein -
KU514_RS05360 (KU514_05325) 1041399..1041683 + 285 WP_001004401.1 hypothetical protein -
KU514_RS05365 (KU514_05330) 1041745..1041963 + 219 WP_000005886.1 hypothetical protein -
KU514_RS05370 (KU514_05335) 1042459..1042659 - 201 WP_001059082.1 cold-shock protein -
KU514_RS05375 (KU514_05340) 1043016..1043702 - 687 WP_001641381.1 thermonuclease family protein -
KU514_RS05380 (KU514_05345) 1044043..1044513 - 471 WP_000824467.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1035236..1045869 10633
- flank IS/Tn - - 1036070..1037716 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208557 WP_000052076.1 NZ_CP077919:1040366-1040554 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208557 NZ_CP103674:c2728792-2728689 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208557 WP_001059690.1 NZ_CP077919:1040077-1040337 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208557 NZ_CP103674:2728676-2728885 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References