Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2039934..2040411 Replicon chromosome
Accession NZ_CP077917
Organism Staphylococcus aureus strain 280

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU509_RS10170 Protein ID WP_000052076.1
Coordinates 2039934..2040122 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU509_RS10175 Protein ID WP_001059690.1
Coordinates 2040151..2040411 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU509_RS10140 (2035937) 2035937..2036446 + 510 WP_000824480.1 hypothetical protein -
KU509_RS10145 (2036787) 2036787..2037473 + 687 WP_001641381.1 thermonuclease family protein -
KU509_RS10150 (2037830) 2037830..2038030 + 201 WP_001059082.1 cold-shock protein -
KU509_RS10155 (2038525) 2038525..2038743 - 219 WP_000005889.1 hypothetical protein -
KU509_RS10160 (2038805) 2038805..2039089 - 285 WP_001004395.1 hypothetical protein -
KU509_RS10165 (2039177) 2039177..2039746 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU509_RS10170 (2039934) 2039934..2040122 - 189 WP_000052076.1 hypothetical protein Toxin
KU509_RS10175 (2040151) 2040151..2040411 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU509_RS10180 (2040751) 2040751..2040954 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU509_RS10185 (2040951) 2040951..2041187 - 237 WP_000368687.1 hypothetical protein -
KU509_RS10190 (2041412) 2041412..2041993 + 582 WP_001140690.1 histidine phosphatase family protein -
KU509_RS10195 (2042066) 2042066..2042683 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
KU509_RS10200 (2042837) 2042837..2043331 - 495 WP_064626748.1 GNAT family N-acetyltransferase -
KU509_RS10205 (2043730) 2043730..2044152 - 423 WP_000974447.1 organic hydroperoxide resistance protein -
KU509_RS10210 (2044300) 2044300..2045016 + 717 WP_000150021.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208556 WP_000052076.1 NZ_CP077917:c2040122-2039934 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208556 NZ_CP103674:c2271793-2271308 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTTAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGGAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208556 WP_001059690.1 NZ_CP077917:c2040411-2040151 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208556 NZ_CP103674:c2272047-2271781 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References