Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 512221..512735 Replicon chromosome
Accession NZ_CP077917
Organism Staphylococcus aureus strain 280

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag KU509_RS02665 Protein ID WP_000581793.1
Coordinates 512221..512430 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU509_RS02670 Protein ID WP_000138932.1
Coordinates 512442..512735 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU509_RS02645 (507730) 507730..509088 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU509_RS02650 (509103) 509103..510173 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KU509_RS02655 (510491) 510491..511693 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU509_RS02660 (511956) 511956..512093 - 138 WP_000828354.1 Lmo0850 family protein -
KU509_RS02665 (512221) 512221..512430 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
KU509_RS02670 (512442) 512442..512735 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU509_RS02675 (512901) 512901..514385 + 1485 WP_000571552.1 cardiolipin synthase -
KU509_RS02680 (514413) 514413..515060 + 648 WP_001187627.1 HD domain-containing protein -
KU509_RS02685 (515772) 515772..516644 - 873 WP_000725802.1 membrane protein insertase YidC -
KU509_RS02690 (516730) 516730..517371 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T208546 WP_000581793.1 NZ_CP077917:c512430-512221 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T208546 NZ_CP103673:c3768567-3768256 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208546 WP_000138932.1 NZ_CP077917:c512735-512442 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208546 NZ_CP103673:c3768259-3767840 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References