Detailed information of TA system TA208543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1894027..1894504
• Replicon: chromosome
• Accession: NZ_CP077916
• Organism: Staphylococcus aureus strain 281

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU502_RS09380
• Protein ID: WP_000052076.1
• Coordinates: 1894027..1894215 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KU502_RS09385
• Protein ID: WP_001059690.1
• Coordinates: 1894244..1894504 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU502_RS09350 (1890030)	1890030..1890539	+	510	WP_000824480.1	hypothetical protein	-
KU502_RS09355 (1890880)	1890880..1891566	+	687	WP_001641381.1	thermonuclease family protein	-
KU502_RS09360 (1891923)	1891923..1892123	+	201	WP_001059082.1	cold-shock protein	-
KU502_RS09365 (1892618)	1892618..1892836	-	219	WP_000005889.1	hypothetical protein	-
KU502_RS09370 (1892898)	1892898..1893182	-	285	WP_001004395.1	hypothetical protein	-
KU502_RS09375 (1893270)	1893270..1893839	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
KU502_RS09380 (1894027)	1894027..1894215	-	189	WP_000052076.1	hypothetical protein	Toxin
KU502_RS09385 (1894244)	1894244..1894504	-	261	WP_001059690.1	hypothetical protein	Antitoxin
KU502_RS09390 (1894844)	1894844..1895047	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KU502_RS09395 (1895044)	1895044..1895280	-	237	WP_000368687.1	hypothetical protein	-
KU502_RS09400 (1895505)	1895505..1896086	+	582	WP_001140690.1	histidine phosphatase family protein	-
KU502_RS09405 (1896159)	1896159..1896776	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
KU502_RS09410 (1896930)	1896930..1897424	-	495	WP_064626748.1	GNAT family N-acetyltransferase	-
KU502_RS09415 (1897823)	1897823..1898245	-	423	WP_000974447.1	organic hydroperoxide resistance protein	-
KU502_RS09420 (1898393)	1898393..1899109	+	717	WP_000150021.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208543 WP_000052076.1 NZ_CP077916:c1894215-1894027 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208543 NZ_CP103673:2326312-2326488 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT208543 WP_001059690.1 NZ_CP077916:c1894504-1894244 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208543 NZ_CP103673:2326534-2326950 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56