208533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 366321..366835 Replicon chromosome
Accession NZ_CP077916
Organism Staphylococcus aureus strain 281

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag KU502_RS01890 Protein ID WP_000581793.1
Coordinates 366321..366530 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU502_RS01895 Protein ID WP_000138932.1
Coordinates 366542..366835 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU502_RS01870 (361830) 361830..363188 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU502_RS01875 (363203) 363203..364273 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KU502_RS01880 (364591) 364591..365793 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU502_RS01885 (366056) 366056..366193 - 138 WP_000828354.1 Lmo0850 family protein -
KU502_RS01890 (366321) 366321..366530 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
KU502_RS01895 (366542) 366542..366835 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU502_RS01900 (367001) 367001..368485 + 1485 WP_000571552.1 cardiolipin synthase -
KU502_RS01905 (368513) 368513..369160 + 648 WP_001187627.1 HD domain-containing protein -
KU502_RS01910 (369872) 369872..370744 - 873 WP_000725802.1 membrane protein insertase YidC -
KU502_RS01915 (370830) 370830..371471 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T208533 WP_000581793.1 NZ_CP077916:c366530-366321 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T208533 NZ_CP103673:233967-234074 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208533 WP_000138932.1 NZ_CP077916:c366835-366542 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208533 NZ_CP103673:c233918-233855 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References