208532

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 346581..347110 Replicon chromosome
Accession NZ_CP077916
Organism Staphylococcus aureus strain 281

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KU502_RS01800 Protein ID WP_000621175.1
Coordinates 346581..346943 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KU502_RS01805 Protein ID WP_000948331.1
Coordinates 346940..347110 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU502_RS01780 (343560) 343560..344330 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
KU502_RS01785 (344305) 344305..344784 - 480 WP_001190829.1 anti-sigma B factor RsbW -
KU502_RS01790 (344786) 344786..345112 - 327 WP_001052491.1 anti-sigma factor antagonist -
KU502_RS01795 (345231) 345231..346232 - 1002 WP_061839378.1 PP2C family protein-serine/threonine phosphatase -
KU502_RS01800 (346581) 346581..346943 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KU502_RS01805 (346940) 346940..347110 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KU502_RS01810 (347195) 347195..348343 - 1149 WP_001281151.1 alanine racemase -
KU502_RS01815 (348409) 348409..348768 - 360 WP_000581200.1 holo-ACP synthase -
KU502_RS01820 (348772) 348772..349263 - 492 WP_001205910.1 PH domain-containing protein -
KU502_RS01825 (349250) 349250..350833 - 1584 WP_001294626.1 PH domain-containing protein -
KU502_RS01830 (350826) 350826..351305 - 480 WP_001287090.1 hypothetical protein -
KU502_RS01835 (351514) 351514..352074 - 561 WP_001092416.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T208532 WP_000621175.1 NZ_CP077916:c346943-346581 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T208532 NZ_CP103673:233484-233591 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT208532 WP_000948331.1 NZ_CP077916:c347110-346940 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT208532 NZ_CP103673:c233435-233372 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References