Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 192513..193289 Replicon chromosome
Accession NZ_CP077916
Organism Staphylococcus aureus strain 281

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KU502_RS00915 Protein ID WP_000031108.1
Coordinates 192513..192665 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag KU502_RS00920 Protein ID WP_001251224.1
Coordinates 192690..193289 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU502_RS00900 (188661) 188661..189482 + 822 WP_000669373.1 RluA family pseudouridine synthase -
KU502_RS00905 (189935) 189935..191320 - 1386 WP_000116230.1 class II fumarate hydratase -
KU502_RS00910 (191516) 191516..191911 - 396 WP_000901023.1 hypothetical protein -
KU502_RS00915 (192513) 192513..192665 - 153 WP_000031108.1 SAS053 family protein Toxin
KU502_RS00920 (192690) 192690..193289 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
KU502_RS00925 (193448) 193448..193918 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KU502_RS00930 (193923) 193923..195050 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
KU502_RS00935 (195201) 195201..195923 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KU502_RS00940 (195916) 195916..197373 - 1458 WP_225806184.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T208531 WP_000031108.1 NZ_CP077916:c192665-192513 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T208531 NZ_CP103673:233000-233107 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT208531 WP_001251224.1 NZ_CP077916:c193289-192690 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT208531 NZ_CP103673:c232942-232888 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References