20853

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1741984..1742493 Replicon chromosome
Accession NC_004461
Organism Staphylococcus epidermidis ATCC 12228

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag SE_RS08205 Protein ID WP_001829980.1
Coordinates 1741984..1742193 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag SE_RS08210 Protein ID WP_001829893.1
Coordinates 1742200..1742493 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SE_RS08185 1737563..1738918 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SE_RS08190 1738930..1740003 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
SE_RS08195 1740394..1741605 + 1212 WP_002486299.1 rod shape-determining protein RodA -
SE_RS08200 1741704..1741841 - 138 WP_001829949.1 hypothetical protein -
SE_RS08205 1741984..1742193 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
SE_RS08210 1742200..1742493 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
SE_RS08215 1742667..1744151 + 1485 WP_002457116.1 cardiolipin synthase -
SE_RS08220 1744333..1744986 + 654 WP_001829983.1 HD domain-containing protein -
SE_RS08225 1745092..1745964 - 873 WP_002470121.1 membrane protein insertase YidC -
SE_RS08230 1746053..1746691 - 639 WP_002505076.1 thiamine phosphate synthase -
SE_RS08235 1746697..1747485 - 789 WP_002469583.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T20853 WP_001829980.1 NC_004461:c1742193-1741984 [Staphylococcus epidermidis ATCC 12228]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T20853 NC_004461:c1742193-1741984 [Staphylococcus epidermidis ATCC 12228]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT20853 WP_001829893.1 NC_004461:c1742493-1742200 [Staphylococcus epidermidis ATCC 12228]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT20853 NC_004461:c1742493-1742200 [Staphylococcus epidermidis ATCC 12228]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References