20852

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1730779..1731308 Replicon chromosome
Accession NC_004461
Organism Staphylococcus epidermidis ATCC 12228

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag SE_RS08145 Protein ID WP_001829891.1
Coordinates 1730779..1731141 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag SE_RS08150 Protein ID WP_001829931.1
Coordinates 1731138..1731308 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SE_RS08125 1727781..1728551 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
SE_RS08130 1728526..1729005 - 480 WP_001829903.1 anti-sigma B factor RsbW -
SE_RS08135 1729007..1729333 - 327 WP_001829952.1 anti-sigma factor antagonist -
SE_RS08140 1729433..1730434 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
SE_RS08145 1730779..1731141 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SE_RS08150 1731138..1731308 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SE_RS08155 1731395..1732543 - 1149 WP_002457107.1 alanine racemase -
SE_RS08160 1732610..1732963 - 354 WP_002457108.1 holo-ACP synthase -
SE_RS08165 1733011..1733520 - 510 WP_002457109.1 PH domain-containing protein -
SE_RS08170 1733507..1735012 - 1506 WP_002457110.1 PH domain-containing protein -
SE_RS08175 1735005..1735484 - 480 WP_002457111.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T20852 WP_001829891.1 NC_004461:c1731141-1730779 [Staphylococcus epidermidis ATCC 12228]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T20852 NC_004461:c1731141-1730779 [Staphylococcus epidermidis ATCC 12228]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT20852 WP_001829931.1 NC_004461:c1731308-1731138 [Staphylococcus epidermidis ATCC 12228]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT20852 NC_004461:c1731308-1731138 [Staphylococcus epidermidis ATCC 12228]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References