Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1039696..1040173 Replicon chromosome
Accession NZ_CP077915
Organism Staphylococcus aureus strain 282

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU535_RS05030 Protein ID WP_000052076.1
Coordinates 1039985..1040173 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU535_RS05025 Protein ID WP_001059690.1
Coordinates 1039696..1039956 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU535_RS04995 (KU535_04965) 1034855..1035349 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU535_RS05000 (KU535_04970) 1035689..1037335 + 1647 WP_000277718.1 IS1182 family transposase -
KU535_RS05005 (KU535_04975) 1037423..1038040 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
KU535_RS05010 (KU535_04980) 1038113..1038694 - 582 WP_001140693.1 histidine phosphatase family protein -
KU535_RS05015 (KU535_04985) 1038919..1039155 + 237 WP_000368687.1 hypothetical protein -
KU535_RS05020 (KU535_04990) 1039152..1039355 - 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
KU535_RS05025 (KU535_04995) 1039696..1039956 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU535_RS05030 (KU535_05000) 1039985..1040173 + 189 WP_000052076.1 hypothetical protein Toxin
KU535_RS05035 (KU535_05005) 1040361..1040930 + 570 Protein_1003 hypothetical protein -
KU535_RS05040 (KU535_05010) 1041018..1041302 + 285 WP_001004401.1 hypothetical protein -
KU535_RS05045 (KU535_05015) 1041364..1041582 + 219 WP_000005886.1 hypothetical protein -
KU535_RS05050 (KU535_05020) 1042078..1042278 - 201 WP_001059082.1 cold-shock protein -
KU535_RS05055 (KU535_05025) 1042635..1043321 - 687 WP_001641381.1 thermonuclease family protein -
KU535_RS05060 (KU535_05030) 1043662..1044132 - 471 WP_000824467.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1035689..1037335 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208519 WP_000052076.1 NZ_CP077915:1039985-1040173 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208519 NZ_CP103672:3011112-3011219 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208519 WP_001059690.1 NZ_CP077915:1039696-1039956 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208519 NZ_CP103672:c3011055-3011000 [Escherichia coli O25b:H4-ST131]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References