Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1626206..1626765 Replicon chromosome
Accession NC_004460
Organism Vibrio vulnificus CMCP6

Toxin (Protein)


Gene name relE Uniprot ID A0A3Q0L0M9
Locus tag VV1_RS22050 Protein ID WP_011082349.1
Coordinates 1626487..1626765 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3Q0L0M2
Locus tag VV1_RS22045 Protein ID WP_011082348.1
Coordinates 1626206..1626490 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV1_RS22015 1621654..1622679 + 1026 WP_197672410.1 L-threonine 3-dehydrogenase -
VV1_RS22020 1622751..1623248 - 498 WP_052298483.1 hypothetical protein -
VV1_RS22025 1623274..1623804 - 531 WP_043921220.1 hypothetical protein -
VV1_RS22030 1624076..1624585 - 510 WP_011082345.1 hypothetical protein -
VV1_RS22035 1624662..1624925 - 264 WP_011082346.1 hypothetical protein -
VV1_RS22040 1625163..1625972 - 810 WP_043921280.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
VV1_RS22045 1626206..1626490 + 285 WP_011082348.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VV1_RS22050 1626487..1626765 + 279 WP_011082349.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VV1_RS24170 1626794..1626886 - 93 WP_079386045.1 DUF3265 domain-containing protein -
VV1_RS24785 1626915..1627196 - 282 WP_133295540.1 hypothetical protein -
VV1_RS22055 1627201..1627458 - 258 WP_011082350.1 hypothetical protein -
VV1_RS22060 1627468..1627968 - 501 WP_038939959.1 hypothetical protein -
VV1_RS22065 1628255..1629901 - 1647 WP_011082352.1 hypothetical protein -
VV1_RS22070 1630792..1631307 - 516 WP_011082353.1 lipocalin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1621648..1629901 8253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10932.66 Da        Isoelectric Point: 4.2397

>T20851 WP_011082349.1 NC_004460:1626487-1626765 [Vibrio vulnificus CMCP6]
MILWEEESLNDREKIFEFLYDFNPDVPEKTDNLIEAKVENLLEQPLMGVQRDSILGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T20851 NC_004460:1626487-1626765 [Vibrio vulnificus CMCP6]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGTGCC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATAGCA
TCCTCGGTCGATTACTCATTATTCCTGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT20851 WP_011082348.1 NC_004460:1626206-1626490 [Vibrio vulnificus CMCP6]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT20851 NC_004460:1626206-1626490 [Vibrio vulnificus CMCP6]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L0M9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0L0M2

References