Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1993037..1993813 Replicon chromosome
Accession NZ_CP077911
Organism Staphylococcus aureus strain 318

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KU501_RS09635 Protein ID WP_000031108.1
Coordinates 1993037..1993189 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag KU501_RS09640 Protein ID WP_225798528.1
Coordinates 1993214..1993813 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU501_RS09620 (1989183) 1989183..1990004 + 822 WP_000669380.1 RluA family pseudouridine synthase -
KU501_RS09625 (1990460) 1990460..1991845 - 1386 WP_000116227.1 class II fumarate hydratase -
KU501_RS09630 (1992041) 1992041..1992436 - 396 WP_000901019.1 hypothetical protein -
KU501_RS09635 (1993037) 1993037..1993189 - 153 WP_000031108.1 SAS053 family protein Toxin
KU501_RS09640 (1993214) 1993214..1993813 - 600 WP_225798528.1 glucosamine-6-phosphate isomerase Antitoxin
KU501_RS09645 (1993972) 1993972..1994442 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KU501_RS09650 (1994447) 1994447..1995574 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
KU501_RS09655 (1995725) 1995725..1996447 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KU501_RS09660 (1996440) 1996440..1997897 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T208508 WP_000031108.1 NZ_CP077911:c1993189-1993037 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T208508 NZ_CP103672:186695-186802 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22426.61 Da        Isoelectric Point: 5.3978

>AT208508 WP_225798528.1 NZ_CP077911:c1993813-1993214 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TRFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT208508 NZ_CP103672:c186638-186581 [Escherichia coli O25b:H4-ST131]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References