Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 875220..875697 Replicon chromosome
Accession NZ_CP077911
Organism Staphylococcus aureus strain 318

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU501_RS04145 Protein ID WP_000052076.1
Coordinates 875220..875408 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU501_RS04150 Protein ID WP_001059690.1
Coordinates 875437..875697 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU501_RS04115 (871173) 871173..871730 + 558 WP_000824491.1 hypothetical protein -
KU501_RS04120 (872071) 872071..872757 + 687 WP_001574556.1 thermonuclease family protein -
KU501_RS04125 (873114) 873114..873314 + 201 WP_001059082.1 cold-shock protein -
KU501_RS04130 (873811) 873811..874029 - 219 WP_000005879.1 hypothetical protein -
KU501_RS04135 (874091) 874091..874375 - 285 WP_001004401.1 hypothetical protein -
KU501_RS04140 (874463) 874463..875032 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
KU501_RS04145 (875220) 875220..875408 - 189 WP_000052076.1 hypothetical protein Toxin
KU501_RS04150 (875437) 875437..875697 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU501_RS04155 (876038) 876038..876241 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU501_RS04160 (876238) 876238..876474 - 237 WP_000368687.1 hypothetical protein -
KU501_RS04165 (876699) 876699..877280 + 582 WP_001140696.1 histidine phosphatase family protein -
KU501_RS04170 (877353) 877353..877970 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
KU501_RS04175 (878126) 878126..878620 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU501_RS04180 (879019) 879019..879441 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
KU501_RS04185 (879589) 879589..880305 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208501 WP_000052076.1 NZ_CP077911:c875408-875220 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208501 NZ_CP103658:c5488-5213 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208501 WP_001059690.1 NZ_CP077911:c875697-875437 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208501 NZ_CP103658:c5772-5488 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References