Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2729286..2729763 Replicon chromosome
Accession NZ_CP077908
Organism Staphylococcus aureus strain 322

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU527_RS13445 Protein ID WP_000052076.1
Coordinates 2729286..2729474 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU527_RS13450 Protein ID WP_001059690.1
Coordinates 2729503..2729763 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU527_RS13415 (2725276) 2725276..2725797 + 522 WP_000824479.1 hypothetical protein -
KU527_RS13420 (2726138) 2726138..2726824 + 687 WP_001622483.1 thermonuclease family protein -
KU527_RS13425 (2727181) 2727181..2727381 + 201 WP_001059082.1 cold-shock protein -
KU527_RS13430 (2727878) 2727878..2728096 - 219 WP_000005884.1 hypothetical protein -
KU527_RS13435 (2728169) 2728169..2728441 - 273 WP_001004400.1 hypothetical protein -
KU527_RS13440 (2728529) 2728529..2729098 - 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
KU527_RS13445 (2729286) 2729286..2729474 - 189 WP_000052076.1 hypothetical protein Toxin
KU527_RS13450 (2729503) 2729503..2729763 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU527_RS13455 (2730104) 2730104..2730307 + 204 WP_061104847.1 sterile alpha motif-like domain-containing protein -
KU527_RS13460 (2730304) 2730304..2730540 - 237 WP_000368687.1 hypothetical protein -
KU527_RS13465 (2730764) 2730764..2731345 + 582 WP_001140696.1 histidine phosphatase family protein -
KU527_RS13470 (2731418) 2731418..2732035 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
KU527_RS13475 (2732191) 2732191..2732685 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU527_RS13480 (2733084) 2733084..2733506 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
KU527_RS13485 (2733654) 2733654..2734370 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208500 WP_000052076.1 NZ_CP077908:c2729474-2729286 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208500 NZ_CP103657:c4881752-4881441 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208500 WP_001059690.1 NZ_CP077908:c2729763-2729503 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208500 NZ_CP103657:c4881440-4881150 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References