Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 2586522..2587087 Replicon chromosome
Accession NC_004459
Organism Vibrio vulnificus CMCP6

Toxin (Protein)


Gene name relE Uniprot ID I3NI62
Locus tag VV1_RS12155 Protein ID WP_011080400.1
Coordinates 2586800..2587087 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3NI65
Locus tag VV1_RS12150 Protein ID WP_011080399.1
Coordinates 2586522..2586803 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV1_RS24945 2582401..2582526 + 126 WP_080553517.1 DUF3265 domain-containing protein -
VV1_RS12125 2582536..2582991 + 456 WP_011080395.1 GNAT family N-acetyltransferase -
VV1_RS12130 2583137..2583634 + 498 WP_043921032.1 hypothetical protein -
VV1_RS12135 2583789..2584577 + 789 WP_011080396.1 hypothetical protein -
VV1_RS12140 2584902..2585231 + 330 WP_011080397.1 hypothetical protein -
VV1_RS23925 2585246..2585338 + 93 WP_005377014.1 DUF3265 domain-containing protein -
VV1_RS12145 2585374..2585853 + 480 WP_011080398.1 GNAT family N-acetyltransferase -
VV1_RS23930 2585835..2585978 + 144 WP_080553518.1 DUF3265 domain-containing protein -
VV1_RS12150 2586522..2586803 + 282 WP_011080399.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VV1_RS12155 2586800..2587087 + 288 WP_011080400.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VV1_RS12160 2587127..2588095 - 969 WP_011080401.1 IS30-like element ISVa6 family transposase -
VV1_RS24425 2588126..2588362 + 237 WP_133295521.1 DUF3265 domain-containing protein -
VV1_RS12165 2588332..2588748 + 417 WP_011150394.1 hypothetical protein -
VV1_RS23940 2588763..2588855 + 93 WP_079751666.1 DUF3265 domain-containing protein -
VV1_RS12170 2588903..2589271 + 369 WP_011080402.1 VOC family protein -
VV1_RS23945 2589286..2589468 + 183 WP_080553470.1 DUF3265 domain-containing protein -
VV1_RS23950 2589479..2589649 + 171 WP_011080403.1 transposase -
VV1_RS24430 2589774..2590625 + 852 WP_011080404.1 IS3 family transposase -
VV1_RS12185 2590739..2591128 + 390 WP_039553776.1 hypothetical protein -
VV1_RS24435 2591274..2591378 + 105 Protein_2442 DUF3265 domain-containing protein -
VV1_RS24440 2591379..2591773 - 395 Protein_2443 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2439594..2596480 156886
- flank IS/Tn - - 2587127..2587903 776
- inside Integron - - 2509330..2589649 80319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.69 Da        Isoelectric Point: 5.0872

>T20850 WP_011080400.1 NC_004459:2586800-2587087 [Vibrio vulnificus CMCP6]
MKVVWSPLALQKLGDAAEFISLDNPVAAESWVNEVFDKTELLSNMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQMLTESDV

Download         Length: 288 bp

>T20850 NC_004459:2586800-2587087 [Vibrio vulnificus CMCP6]
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTTATTTCACTGGATAACCCAGTGGC
AGCAGAAAGCTGGGTTAATGAGGTTTTCGATAAAACCGAACTTCTCTCAAATATGCCTGAAATGGGGCGAATGGTTCCTG
AGTTACCTCATACTAATTATCGTGAAATCCTTTTTGGCCACTACCGAATCATATATAGCCTCAGTCATGAAATTCGTGTC
CTGACAGTAAGAAATTGTCGTCAAATGCTAACGGAAAGTGATGTGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10426.96 Da        Isoelectric Point: 5.8719

>AT20850 WP_011080399.1 NC_004459:2586522-2586803 [Vibrio vulnificus CMCP6]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Download         Length: 282 bp

>AT20850 NC_004459:2586522-2586803 [Vibrio vulnificus CMCP6]
ATGAGCCGTATCCACTTTGACCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGCGTAACGTCATTTATTAAACAGAT
TAACGAAACTCGTAGACCATTAGTAATCACACAACGTGGTAAGGGTGTTGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CAATGCAGGAGAAGATCGAGTTACTGGAAGAAATGCGTACTGCTGAAGCACAATTAGCTTCAGGTTTAGGTGTTTCCAAT
GAAGACGCTCGCGCTCAAGTGTTGGGGCGTATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L634

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0MQY5

References