Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1239192..1239706 Replicon chromosome
Accession NZ_CP077908
Organism Staphylococcus aureus strain 322

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU527_RS06245 Protein ID WP_000581795.1
Coordinates 1239192..1239401 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag KU527_RS06250 Protein ID WP_000138930.1
Coordinates 1239413..1239706 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU527_RS06225 (1234700) 1234700..1236058 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU527_RS06230 (1236073) 1236073..1237143 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU527_RS06235 (1237461) 1237461..1238663 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU527_RS06240 (1238927) 1238927..1239064 - 138 WP_000828354.1 Lmo0850 family protein -
KU527_RS06245 (1239192) 1239192..1239401 - 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU527_RS06250 (1239413) 1239413..1239706 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU527_RS06255 (1239872) 1239872..1241356 + 1485 WP_000571562.1 cardiolipin synthase -
KU527_RS06260 (1241384) 1241384..1242031 + 648 WP_001187625.1 HD domain-containing protein -
KU527_RS06265 (1242581) 1242581..1243453 - 873 WP_000725802.1 membrane protein insertase YidC -
KU527_RS06270 (1243539) 1243539..1244180 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208496 WP_000581795.1 NZ_CP077908:c1239401-1239192 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208496 NZ_CP103657:c4326376-4326089 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT208496 WP_000138930.1 NZ_CP077908:c1239706-1239413 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208496 NZ_CP103657:c4326102-4325800 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References