Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 2579918..2580684 Replicon chromosome
Accession NC_004459
Organism Vibrio vulnificus CMCP6

Toxin (Protein)


Gene name - Uniprot ID A0A3Q0L5V0
Locus tag VV1_RS12110 Protein ID WP_011080392.1
Coordinates 2579918..2580415 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A3Q0L609
Locus tag VV1_RS12115 Protein ID WP_011080393.1
Coordinates 2580412..2580684 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV1_RS12075 2575038..2575505 + 468 WP_043921028.1 cold shock domain-containing protein -
VV1_RS24940 2575531..2575623 + 93 Protein_2411 DUF3265 domain-containing protein -
VV1_RS12085 2575982..2576574 + 593 Protein_2412 DUF3265 domain-containing protein -
VV1_RS23900 2576589..2576756 + 168 WP_080553468.1 DUF3265 domain-containing protein -
VV1_RS12090 2576735..2577121 + 387 WP_000260420.1 tautomerase family protein -
VV1_RS23905 2577118..2577258 + 141 Protein_2415 DUF3265 domain-containing protein -
VV1_RS12095 2577258..2578004 + 747 WP_043921030.1 hypothetical protein -
VV1_RS24410 2578458..2578583 + 126 Protein_2417 DUF3265 domain-containing protein -
VV1_RS12100 2578729..2579259 + 531 WP_043921031.1 hypothetical protein -
VV1_RS23910 2579773..2579895 + 123 WP_080553516.1 DUF3265 domain-containing protein -
VV1_RS12110 2579918..2580415 - 498 WP_011080392.1 GNAT family N-acetyltransferase Toxin
VV1_RS12115 2580412..2580684 - 273 WP_011080393.1 DUF1778 domain-containing protein Antitoxin
VV1_RS12120 2581350..2582319 - 970 Protein_2422 IS30 family transposase -
VV1_RS24945 2582401..2582526 + 126 WP_080553517.1 DUF3265 domain-containing protein -
VV1_RS12125 2582536..2582991 + 456 WP_011080395.1 GNAT family N-acetyltransferase -
VV1_RS12130 2583137..2583634 + 498 WP_043921032.1 hypothetical protein -
VV1_RS12135 2583789..2584577 + 789 WP_011080396.1 hypothetical protein -
VV1_RS12140 2584902..2585231 + 330 WP_011080397.1 hypothetical protein -
VV1_RS23925 2585246..2585338 + 93 WP_005377014.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2439594..2596480 156886
- inside Integron - - 2509330..2589649 80319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18486.13 Da        Isoelectric Point: 8.0487

>T20849 WP_011080392.1 NC_004459:c2580415-2579918 [Vibrio vulnificus CMCP6]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T20849 NC_004459:c2580415-2579918 [Vibrio vulnificus CMCP6]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAAAAAGACAACACCAGAACGTTTGTTTTGGAAGATGATAACGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAGTTACAAAAAAAACACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATTGACGCACTCAGAAAGCTATTAGCTGCAAGTGATAGCGTTGCATTTCCAGTTGTCATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTGAAGACGCTGAAAATAAACTCTTCATCACCATTGCTGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9720.25 Da        Isoelectric Point: 8.5960

>AT20849 WP_011080393.1 NC_004459:c2580684-2580412 [Vibrio vulnificus CMCP6]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQSSKLKA
AADRYESKIQ

Download         Length: 273 bp

>AT20849 NC_004459:c2580684-2580412 [Vibrio vulnificus CMCP6]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGACCGCCCTGCAACACAGAGCTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5V0

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0L609

References