Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2268691..2269205 Replicon chromosome
Accession NZ_CP077899
Organism Staphylococcus aureus strain 324

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU505_RS11210 Protein ID WP_000581795.1
Coordinates 2268691..2268900 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KU505_RS11215 Protein ID WP_000138934.1
Coordinates 2268912..2269205 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU505_RS11190 (2264199) 2264199..2265557 - 1359 WP_060649657.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU505_RS11195 (2265572) 2265572..2266642 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU505_RS11200 (2266960) 2266960..2268162 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU505_RS11205 (2268426) 2268426..2268563 - 138 WP_000828354.1 Lmo0850 family protein -
KU505_RS11210 (2268691) 2268691..2268900 - 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU505_RS11215 (2268912) 2268912..2269205 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU505_RS11220 (2269371) 2269371..2270855 + 1485 WP_000571558.1 cardiolipin synthase -
KU505_RS11225 (2270883) 2270883..2271530 + 648 WP_001187624.1 HD domain-containing protein -
KU505_RS11230 (2272280) 2272280..2273152 - 873 WP_000725802.1 membrane protein insertase YidC -
KU505_RS11235 (2273238) 2273238..2273879 - 642 WP_225805902.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208489 WP_000581795.1 NZ_CP077899:c2268900-2268691 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208489 NZ_CP103657:2881235-2881342 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT208489 WP_000138934.1 NZ_CP077899:c2269205-2268912 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208489 NZ_CP103657:c2881185-2881128 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References