Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2248948..2249477 Replicon chromosome
Accession NZ_CP077899
Organism Staphylococcus aureus strain 324

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KU505_RS11120 Protein ID WP_000621175.1
Coordinates 2248948..2249310 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KU505_RS11125 Protein ID WP_000948331.1
Coordinates 2249307..2249477 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU505_RS11100 (2245927) 2245927..2246697 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
KU505_RS11105 (2246672) 2246672..2247151 - 480 WP_225805901.1 anti-sigma B factor RsbW -
KU505_RS11110 (2247153) 2247153..2247479 - 327 WP_001052491.1 anti-sigma factor antagonist -
KU505_RS11115 (2247598) 2247598..2248599 - 1002 WP_000390826.1 PP2C family protein-serine/threonine phosphatase -
KU505_RS11120 (2248948) 2248948..2249310 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KU505_RS11125 (2249307) 2249307..2249477 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KU505_RS11130 (2249562) 2249562..2250710 - 1149 WP_001281140.1 alanine racemase -
KU505_RS11135 (2250776) 2250776..2251135 - 360 WP_000581197.1 holo-ACP synthase -
KU505_RS11140 (2251139) 2251139..2251630 - 492 WP_001205909.1 PH domain-containing protein -
KU505_RS11145 (2251617) 2251617..2253200 - 1584 WP_001294639.1 PH domain-containing protein -
KU505_RS11150 (2253193) 2253193..2253672 - 480 WP_001287076.1 hypothetical protein -
KU505_RS11155 (2253880) 2253880..2254440 - 561 WP_001092421.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T208488 WP_000621175.1 NZ_CP077899:c2249310-2248948 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T208488 NZ_CP103657:2880700-2880807 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT208488 WP_000948331.1 NZ_CP077899:c2249477-2249307 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT208488 NZ_CP103657:c2880647-2880586 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References