Detailed information of TA system TA208485

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2025254..2026030
• Replicon: chromosome
• Accession: NZ_CP077899
• Organism: Staphylococcus aureus strain 324

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KU505_RS09700
• Protein ID: WP_000031109.1
• Coordinates: 2025254..2025406 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KU505_RS09705
• Protein ID: WP_001251224.1
• Coordinates: 2025431..2026030 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU505_RS09685 (2021173)	2021173..2021994	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
KU505_RS09690 (2022451)	2022451..2023836	-	1386	WP_000116238.1	class II fumarate hydratase	-
KU505_RS09695 (2024032)	2024032..2024427	-	396	WP_000901023.1	hypothetical protein	-
KU505_RS09700 (2025254)	2025254..2025406	-	153	WP_000031109.1	SAS053 family protein	Toxin
KU505_RS09705 (2025431)	2025431..2026030	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KU505_RS09710 (2026189)	2026189..2026659	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KU505_RS09715 (2026664)	2026664..2027791	-	1128	WP_000379991.1	tRNA epoxyqueuosine(34) reductase QueG	-
KU505_RS09720 (2027942)	2027942..2028664	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KU505_RS09725 (2028657)	2028657..2030114	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T208485 WP_000031109.1 NZ_CP077899:c2025406-2025254 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T208485 NZ_CP103657:1973318-1973572 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT208485 WP_001251224.1 NZ_CP077899:c2026030-2025431 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT208485 NZ_CP103657:1973070-1973321 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: W8U4V4