Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2570254..2570792 Replicon chromosome
Accession NC_004459
Organism Vibrio vulnificus CMCP6

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag VV1_RS12045 Protein ID WP_001247271.1
Coordinates 2570254..2570553 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag VV1_RS12050 Protein ID WP_011080384.1
Coordinates 2570550..2570792 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV1_RS12025 2566007..2566468 + 462 WP_043921024.1 GNAT family N-acetyltransferase -
VV1_RS24390 2566465..2566575 + 111 Protein_2394 DUF3265 domain-containing protein -
VV1_RS23845 2567085..2567174 + 90 WP_071936877.1 DUF3265 domain-containing protein -
VV1_RS23850 2567988..2568203 + 216 WP_080553462.1 DUF3265 domain-containing protein -
VV1_RS23860 2569020..2569130 + 111 WP_080553513.1 DUF3265 domain-containing protein -
VV1_RS12035 2569164..2569670 + 507 WP_043921025.1 GNAT family N-acetyltransferase -
VV1_RS23865 2569680..2569802 + 123 Protein_2399 DUF3265 domain-containing protein -
VV1_RS24700 2569818..2570111 + 294 WP_043921026.1 hypothetical protein -
VV1_RS23870 2570136..2570246 + 111 WP_080553514.1 DUF3265 domain-containing protein -
VV1_RS12045 2570254..2570553 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VV1_RS12050 2570550..2570792 - 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
VV1_RS23885 2571783..2571941 + 159 WP_080553466.1 DUF3265 domain-containing protein -
VV1_RS12060 2571934..2572398 + 465 WP_011080386.1 ASCH domain-containing protein -
VV1_RS12065 2572432..2573400 - 969 WP_011080312.1 IS30-like element ISVa6 family transposase -
VV1_RS12070 2573734..2574420 + 687 WP_011080387.1 toll/interleukin-1 receptor domain-containing protein -
VV1_RS23890 2574435..2574527 + 93 WP_078531873.1 DUF3265 domain-containing protein -
VV1_RS23895 2574889..2575023 + 135 WP_080553515.1 DUF3265 domain-containing protein -
VV1_RS12075 2575038..2575505 + 468 WP_043921028.1 cold shock domain-containing protein -
VV1_RS24940 2575531..2575623 + 93 Protein_2411 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2439594..2596480 156886
- flank IS/Tn - - 2572432..2573208 776
- inside Integron - - 2509330..2589649 80319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T20848 WP_001247271.1 NC_004459:c2570553-2570254 [Vibrio vulnificus CMCP6]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T20848 NC_004459:c2570553-2570254 [Vibrio vulnificus CMCP6]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAAATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT20848 WP_011080384.1 NC_004459:c2570792-2570550 [Vibrio vulnificus CMCP6]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT20848 NC_004459:c2570792-2570550 [Vibrio vulnificus CMCP6]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGTCGCTATGG
CTCTGCAAGTGAAGTCATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References