Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 953816..954293 Replicon chromosome
Accession NZ_CP077899
Organism Staphylococcus aureus strain 324

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU505_RS04465 Protein ID WP_000052076.1
Coordinates 953816..954004 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU505_RS04470 Protein ID WP_001059690.1
Coordinates 954033..954293 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU505_RS04435 (949839) 949839..950309 + 471 WP_000824466.1 hypothetical protein -
KU505_RS04440 (950651) 950651..951319 + 669 WP_000141442.1 thermonuclease family protein -
KU505_RS04445 (951682) 951682..951882 + 201 WP_001059082.1 cold-shock protein -
KU505_RS04450 (952407) 952407..952625 - 219 WP_000005884.1 hypothetical protein -
KU505_RS04455 (952687) 952687..952971 - 285 WP_001004401.1 hypothetical protein -
KU505_RS04460 (953059) 953059..953628 - 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
KU505_RS04465 (953816) 953816..954004 - 189 WP_000052076.1 hypothetical protein Toxin
KU505_RS04470 (954033) 954033..954293 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU505_RS04475 (954634) 954634..954837 + 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
KU505_RS04480 (954834) 954834..955070 - 237 WP_000368687.1 hypothetical protein -
KU505_RS04485 (955294) 955294..955875 + 582 WP_001140696.1 histidine phosphatase family protein -
KU505_RS04490 (955948) 955948..956565 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
KU505_RS04495 (956721) 956721..957215 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU505_RS04500 (957614) 957614..958036 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
KU505_RS04505 (958184) 958184..958900 + 717 WP_000150034.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208478 WP_000052076.1 NZ_CP077899:c954004-953816 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208478 NZ_CP103657:224203-224310 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208478 WP_001059690.1 NZ_CP077899:c954293-954033 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208478 NZ_CP103657:c224154-224091 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References