Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2066097..2066611 Replicon chromosome
Accession NZ_CP077898
Organism Staphylococcus aureus strain 327

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU503_RS10385 Protein ID WP_000581795.1
Coordinates 2066097..2066306 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag KU503_RS10390 Protein ID WP_000138930.1
Coordinates 2066318..2066611 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU503_RS10365 (2061605) 2061605..2062963 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU503_RS10370 (2062978) 2062978..2064048 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU503_RS10375 (2064366) 2064366..2065568 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU503_RS10380 (2065832) 2065832..2065969 - 138 WP_000828354.1 Lmo0850 family protein -
KU503_RS10385 (2066097) 2066097..2066306 - 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU503_RS10390 (2066318) 2066318..2066611 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU503_RS10395 (2066777) 2066777..2068261 + 1485 WP_000571562.1 cardiolipin synthase -
KU503_RS10400 (2068289) 2068289..2068936 + 648 WP_001187625.1 HD domain-containing protein -
KU503_RS10405 (2069486) 2069486..2070358 - 873 WP_000725802.1 membrane protein insertase YidC -
KU503_RS10410 (2070444) 2070444..2071085 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208475 WP_000581795.1 NZ_CP077898:c2066306-2066097 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208475 NZ_CP103655:c6090-5785 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT208475 WP_000138930.1 NZ_CP077898:c2066611-2066318 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208475 NZ_CP103655:c6310-6092 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References