Detailed information of TA system TA208471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1852912..1853688
• Replicon: chromosome
• Accession: NZ_CP077898
• Organism: Staphylococcus aureus strain 327

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KU503_RS09080
• Protein ID: WP_000031109.1
• Coordinates: 1852912..1853064 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KU503_RS09085
• Protein ID: WP_001251224.1
• Coordinates: 1853089..1853688 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU503_RS09065 (1848718)	1848718..1849539	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
KU503_RS09070 (1849996)	1849996..1851381	-	1386	WP_000116239.1	class II fumarate hydratase	-
KU503_RS09075 (1851577)	1851577..1851972	-	396	WP_000901019.1	hypothetical protein	-
KU503_RS09080 (1852912)	1852912..1853064	-	153	WP_000031109.1	SAS053 family protein	Toxin
KU503_RS09085 (1853089)	1853089..1853688	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KU503_RS09090 (1853847)	1853847..1854317	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KU503_RS09095 (1854322)	1854322..1855449	-	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
KU503_RS09100 (1855600)	1855600..1856322	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KU503_RS09105 (1856315)	1856315..1857772	-	1458	WP_000649916.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T208471 WP_000031109.1 NZ_CP077898:c1853064-1852912 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T208471 NZ_CP103654:c4699850-4699509 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT208471 WP_001251224.1 NZ_CP077898:c1853688-1853089 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT208471 NZ_CP103654:c4700212-4699871 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4