Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 791956..792433 Replicon chromosome
Accession NZ_CP077898
Organism Staphylococcus aureus strain 327

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU503_RS03825 Protein ID WP_000052076.1
Coordinates 791956..792144 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU503_RS03830 Protein ID WP_001059690.1
Coordinates 792173..792433 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU503_RS03795 (787946) 787946..788467 + 522 WP_000824479.1 hypothetical protein -
KU503_RS03800 (788808) 788808..789494 + 687 WP_001622483.1 thermonuclease family protein -
KU503_RS03805 (789851) 789851..790051 + 201 WP_001059082.1 cold-shock protein -
KU503_RS03810 (790548) 790548..790766 - 219 WP_000005884.1 hypothetical protein -
KU503_RS03815 (790839) 790839..791111 - 273 WP_001004400.1 hypothetical protein -
KU503_RS03820 (791199) 791199..791768 - 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
KU503_RS03825 (791956) 791956..792144 - 189 WP_000052076.1 hypothetical protein Toxin
KU503_RS03830 (792173) 792173..792433 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU503_RS03835 (792774) 792774..792977 + 204 WP_061104847.1 sterile alpha motif-like domain-containing protein -
KU503_RS03840 (792974) 792974..793210 - 237 WP_000368687.1 hypothetical protein -
KU503_RS03845 (793434) 793434..794015 + 582 WP_001140696.1 histidine phosphatase family protein -
KU503_RS03850 (794088) 794088..794705 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
KU503_RS03855 (794861) 794861..795355 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU503_RS03860 (795754) 795754..796176 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
KU503_RS03865 (796324) 796324..797040 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208470 WP_000052076.1 NZ_CP077898:c792144-791956 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208470 NZ_CP103654:c4669378-4668845 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208470 WP_001059690.1 NZ_CP077898:c792433-792173 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208470 NZ_CP103654:c4669655-4669389 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References