Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2474998..2475545 Replicon chromosome
Accession NC_004459
Organism Vibrio vulnificus CMCP6

Toxin (Protein)


Gene name relE Uniprot ID I3NI64
Locus tag VV1_RS11535 Protein ID WP_011080278.1
Coordinates 2475243..2475545 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag VV1_RS11530 Protein ID WP_005448240.1
Coordinates 2474998..2475255 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV1_RS11510 2471799..2472674 + 876 WP_011080297.1 hypothetical protein -
VV1_RS11515 2472653..2473102 + 450 WP_133295512.1 hypothetical protein -
VV1_RS11520 2473317..2473664 + 348 WP_043920995.1 hypothetical protein -
VV1_RS23355 2473687..2473827 + 141 WP_080553430.1 DUF3265 domain-containing protein -
VV1_RS11525 2473811..2474317 + 507 WP_043920996.1 GNAT family N-acetyltransferase -
VV1_RS23360 2474327..2474455 + 129 WP_080553492.1 DUF3265 domain-containing protein -
VV1_RS23370 2474768..2474927 + 160 Protein_2213 DUF3265 domain-containing protein -
VV1_RS11530 2474998..2475255 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VV1_RS11535 2475243..2475545 + 303 WP_011080278.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VV1_RS24310 2475581..2475675 + 95 Protein_2216 DUF3265 domain-containing protein -
VV1_RS11540 2476179..2476673 + 495 WP_011080299.1 GNAT family N-acetyltransferase -
VV1_RS11545 2476810..2477553 + 744 WP_043920997.1 hypothetical protein -
VV1_RS23375 2478050..2478166 + 117 WP_080553431.1 DUF3265 domain-containing protein -
VV1_RS11550 2478194..2479162 + 969 WP_011080301.1 hypothetical protein -
VV1_RS11555 2479164..2479550 + 387 WP_011080302.1 hypothetical protein -
VV1_RS23380 2479571..2479663 + 93 WP_193387252.1 DUF3265 domain-containing protein -
VV1_RS11560 2479700..2480041 + 342 WP_043920998.1 hypothetical protein -
VV1_RS23385 2480064..2480258 + 195 WP_080553433.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2439594..2596480 156886
- inside Integron - - 2438314..2501294 62980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11624.53 Da        Isoelectric Point: 4.8951

>T20847 WP_011080278.1 NC_004459:2475243-2475545 [Vibrio vulnificus CMCP6]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQAIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T20847 NC_004459:2475243-2475545 [Vibrio vulnificus CMCP6]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAGCGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCGC
CTGAACTAGAACATCTAAGTTATCGTGAAGTTGTAGTTAATCCGTGCCGTATTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTTTGTTTGTTATGCGTGCTGAGAGAGACTTGCGTAAGTTCCTATTGAGCAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT20847 WP_005448240.1 NC_004459:2474998-2475255 [Vibrio vulnificus CMCP6]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT20847 NC_004459:2474998-2475255 [Vibrio vulnificus CMCP6]
ATGAAAGTAGAACTAGTTACATCACTCAAACGCCAAGCAACAAAGATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTAGCGA
TTCTTGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T4

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References