Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1840596..1841110 Replicon chromosome
Accession NZ_CP077897
Organism Staphylococcus aureus strain 328

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU544_RS09120 Protein ID WP_000581795.1
Coordinates 1840901..1841110 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag KU544_RS09115 Protein ID WP_000138930.1
Coordinates 1840596..1840889 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU544_RS09095 (1836122) 1836122..1836763 + 642 WP_000483162.1 thiamine phosphate synthase -
KU544_RS09100 (1836849) 1836849..1837721 + 873 WP_000725802.1 membrane protein insertase YidC -
KU544_RS09105 (1838271) 1838271..1838918 - 648 WP_001187625.1 HD domain-containing protein -
KU544_RS09110 (1838946) 1838946..1840430 - 1485 WP_000571562.1 cardiolipin synthase -
KU544_RS09115 (1840596) 1840596..1840889 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU544_RS09120 (1840901) 1840901..1841110 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU544_RS09125 (1841238) 1841238..1841375 + 138 WP_000828354.1 Lmo0850 family protein -
KU544_RS09130 (1841639) 1841639..1842841 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU544_RS09135 (1843159) 1843159..1844229 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU544_RS09140 (1844244) 1844244..1845602 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208462 WP_000581795.1 NZ_CP077897:1840901-1841110 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208462 NZ_CP103647:77502-77783 [Escherichia coli]
ATGACTTATGAACTGGAATTTGAGCGCAGGGCCCTGAAAGAATGGCATAAGCTCGGTCATACAGTCCGTGAGCAGTTCAA
AAAGAAACTGTCAGAACGCCTGAAAAATCCAAGGGTCCCTGCTGCCAGGCTACATGGTCATACTGACCGTTATAAAATCA
AGCTTCGTGCATCTGGTTACAGGCTCGTCTATCAGGTGATTGATGAGAAAATTGTTTTGCTCGTTATTGCTGTAGGAAAA
AGGGAAAGCAGTGAGGTCTACCAGATGGCTGATATTCGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT208462 WP_000138930.1 NZ_CP077897:1840596-1840889 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208462 NZ_CP103647:77261-77512 [Escherichia coli]
ATGAGTTACCAGATTTTGACCACGACAGCAGCAAGTATTACTGAGCTGAAAAAAAATCCTATGGGCACGGTAGCCGAAGG
TGAAGGAGGGGCCGTTGCAATCCTGAACCGAAATGAGCCTGCGTTCTACTGTGTCCCTCCGGAACTTTATGCCTACTACC
GGGAGCTCGCCGAAGATGCTGAGCTAAACGCAATTGCTGATGAAAGAATGAAGAATCCGGACATTGTGAAGGTTAGTCTG
GATGACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References