Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2450612..2451159 Replicon chromosome
Accession NC_004459
Organism Vibrio vulnificus CMCP6

Toxin (Protein)


Gene name relE Uniprot ID I3NI64
Locus tag VV1_RS11385 Protein ID WP_011080278.1
Coordinates 2450857..2451159 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag VV1_RS11380 Protein ID WP_005448240.1
Coordinates 2450612..2450869 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV1_RS23255 2445904..2446047 + 144 WP_080553422.1 DUF3265 domain-containing protein -
VV1_RS11365 2446057..2446482 + 426 WP_043920981.1 hypothetical protein -
VV1_RS11370 2446625..2447449 + 825 WP_011080275.1 DUF4393 domain-containing protein -
VV1_RS23260 2447473..2447565 + 93 Protein_2165 DUF3265 domain-containing protein -
VV1_RS23265 2447924..2448079 + 156 WP_080553423.1 DUF3265 domain-containing protein -
VV1_RS11375 2448063..2449367 + 1305 WP_011080276.1 P-loop ATPase -
VV1_RS23275 2449964..2450053 + 90 WP_074190930.1 DUF3265 domain-containing protein -
VV1_RS23285 2450419..2450541 + 123 WP_079764956.1 DUF3265 domain-containing protein -
VV1_RS11380 2450612..2450869 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VV1_RS11385 2450857..2451159 + 303 WP_011080278.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VV1_RS24285 2451195..2451289 + 95 Protein_2172 DUF3265 domain-containing protein -
VV1_RS11390 2451855..2452226 + 372 WP_011080279.1 hypothetical protein -
VV1_RS11395 2452368..2452703 + 336 WP_043920982.1 hypothetical protein -
VV1_RS23290 2453278..2453370 + 93 WP_096030926.1 DUF3265 domain-containing protein -
VV1_RS11400 2453422..2453742 + 321 WP_052298473.1 hypothetical protein -
VV1_RS23295 2453777..2453925 + 149 Protein_2177 DUF3265 domain-containing protein -
VV1_RS11405 2453918..2454727 + 810 WP_011080280.1 hypothetical protein -
VV1_RS23300 2454732..2454908 + 177 WP_080553489.1 DUF3265 domain-containing protein -
VV1_RS11410 2454920..2455378 + 459 WP_043920984.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2439594..2596480 156886
- inside Integron - - 2438314..2501294 62980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11624.53 Da        Isoelectric Point: 4.8951

>T20846 WP_011080278.1 NC_004459:2450857-2451159 [Vibrio vulnificus CMCP6]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQAIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T20846 NC_004459:2450857-2451159 [Vibrio vulnificus CMCP6]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAGCGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCGC
CTGAACTAGAACATCTAAGTTATCGTGAAGTTGTAGTTAATCCGTGCCGTATTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTTTGTTTGTTATGCGTGCTGAGAGAGACTTGCGTAAGTTCCTATTGAGCAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT20846 WP_005448240.1 NC_004459:2450612-2450869 [Vibrio vulnificus CMCP6]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT20846 NC_004459:2450612-2450869 [Vibrio vulnificus CMCP6]
ATGAAAGTAGAACTAGTTACATCACTCAAACGCCAAGCAACAAAGATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTAGCGA
TTCTTGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T4

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References