Detailed information of TA system TA208459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 378607..379136
• Replicon: chromosome
• Accession: NZ_CP077897
• Organism: Staphylococcus aureus strain 328

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: KU544_RS02080
• Protein ID: WP_001103939.1
• Coordinates: 378607..378924 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: KU544_RS02085
• Protein ID: WP_001058494.1
• Coordinates: 378927..379136 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU544_RS02055 (374613)	374613..375254	-	642	WP_001019808.1	hypothetical protein	-
KU544_RS02060 (375251)	375251..375535	-	285	WP_000998185.1	hypothetical protein	-
KU544_RS02065 (375537)	375537..375899	-	363	WP_001039170.1	hypothetical protein	-
KU544_RS02070 (376200)	376200..377657	-	1458	WP_000390453.1	virulence-associated E family protein	-
KU544_RS02075 (377674)	377674..378543	-	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
KU544_RS02080 (378607)	378607..378924	-	318	WP_001103939.1	DUF1474 family protein	Toxin
KU544_RS02085 (378927)	378927..379136	-	210	WP_001058494.1	hypothetical protein	Antitoxin
KU544_RS02090 (379129)	379129..379275	-	147	WP_000784885.1	hypothetical protein	-
KU544_RS02095 (379287)	379287..379505	-	219	WP_000163544.1	helix-turn-helix transcriptional regulator	-
KU544_RS02100 (379541)	379541..379744	-	204	WP_001045296.1	transcriptional regulator	-
KU544_RS02105 (379880)	379880..380683	+	804	WP_000358990.1	helix-turn-helix transcriptional regulator	-
KU544_RS02110 (380673)	380673..381779	+	1107	WP_000149511.1	tyrosine-type recombinase/integrase	-
KU544_RS02120 (382342)	382342..382806	-	465	WP_001085185.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T208459 WP_001103939.1 NZ_CP077897:c378924-378607 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T208459 NZ_CP103646:c184711-184295 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT208459 WP_001058494.1 NZ_CP077897:c379136-378927 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT208459 NZ_CP103646:c184938-184708 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59