Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 350537..351014 Replicon chromosome
Accession NZ_CP077897
Organism Staphylococcus aureus strain 328

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU544_RS01910 Protein ID WP_000052076.1
Coordinates 350826..351014 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU544_RS01905 Protein ID WP_001059690.1
Coordinates 350537..350797 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU544_RS01870 (345930) 345930..346646 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
KU544_RS01875 (346794) 346794..347216 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
KU544_RS01880 (347615) 347615..348109 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU544_RS01885 (348265) 348265..348882 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
KU544_RS01890 (348955) 348955..349536 - 582 WP_001140696.1 histidine phosphatase family protein -
KU544_RS01895 (349760) 349760..349996 + 237 WP_000368687.1 hypothetical protein -
KU544_RS01900 (349993) 349993..350196 - 204 WP_061104847.1 sterile alpha motif-like domain-containing protein -
KU544_RS01905 (350537) 350537..350797 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU544_RS01910 (350826) 350826..351014 + 189 WP_000052076.1 hypothetical protein Toxin
KU544_RS01915 (351202) 351202..351771 + 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
KU544_RS01920 (351859) 351859..352131 + 273 WP_001004400.1 hypothetical protein -
KU544_RS01925 (352204) 352204..352422 + 219 WP_000005884.1 hypothetical protein -
KU544_RS01930 (352919) 352919..353119 - 201 WP_001059082.1 cold-shock protein -
KU544_RS01935 (353476) 353476..354162 - 687 WP_001622483.1 thermonuclease family protein -
KU544_RS01940 (354503) 354503..355024 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208458 WP_000052076.1 NZ_CP077897:350826-351014 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208458 NZ_CP103646:60071-60220 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208458 WP_001059690.1 NZ_CP077897:350537-350797 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208458 NZ_CP103646:c60027-59966 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References