Detailed information of TA system TA208452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1383336..1384112
• Replicon: chromosome
• Accession: NZ_CP077894
• Organism: Staphylococcus aureus strain 329

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KU540_RS07040
• Protein ID: WP_000031109.1
• Coordinates: 1383960..1384112 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KU540_RS07035
• Protein ID: WP_001251224.1
• Coordinates: 1383336..1383935 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU540_RS07015 (1379252)	1379252..1380709	+	1458	WP_000649908.1	ABC transporter permease subunit	-
KU540_RS07020 (1380702)	1380702..1381424	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KU540_RS07025 (1381575)	1381575..1382702	+	1128	WP_000379991.1	tRNA epoxyqueuosine(34) reductase QueG	-
KU540_RS07030 (1382707)	1382707..1383177	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KU540_RS07035 (1383336)	1383336..1383935	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KU540_RS07040 (1383960)	1383960..1384112	+	153	WP_000031109.1	SAS053 family protein	Toxin
KU540_RS07045 (1384939)	1384939..1385334	+	396	WP_000901023.1	hypothetical protein	-
KU540_RS07050 (1385530)	1385530..1386915	+	1386	WP_000116238.1	class II fumarate hydratase	-
KU540_RS07055 (1387372)	1387372..1388193	-	822	WP_000669377.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T208452 WP_000031109.1 NZ_CP077894:1383960-1384112 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T208452 NZ_CP103645:c3817961-3817563 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT208452 WP_001251224.1 NZ_CP077894:1383336-1383935 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT208452 NZ_CP103645:c3818257-3817964 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4