Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2039391..2040952 Replicon chromosome
Accession NC_004459
Organism Vibrio vulnificus CMCP6

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag VV1_RS09680 Protein ID WP_011079939.1
Coordinates 2039624..2040952 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag VV1_RS09675 Protein ID WP_011079938.1
Coordinates 2039391..2039630 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV1_RS09665 2035674..2036981 - 1308 WP_011079936.1 HNH endonuclease -
VV1_RS09670 2036990..2038798 - 1809 WP_011079937.1 ATP-binding protein -
VV1_RS09675 2039391..2039630 + 240 WP_011079938.1 helix-turn-helix domain-containing protein Antitoxin
VV1_RS09680 2039624..2040952 + 1329 WP_011079939.1 type II toxin-antitoxin system HipA family toxin Toxin
VV1_RS09685 2041144..2042466 - 1323 WP_011079940.1 site-specific integrase -
VV1_RS09690 2043151..2043909 + 759 WP_011079942.1 magnesium transporter -
VV1_RS09695 2044047..2045099 + 1053 WP_011079943.1 GGDEF domain-containing protein -
VV1_RS09700 2045302..2045766 + 465 WP_011079944.1 DUF2846 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2016604..2042466 25862


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-55)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49658.03 Da        Isoelectric Point: 9.1007

>T20845 WP_011079939.1 NC_004459:2039624-2040952 [Vibrio vulnificus CMCP6]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSGWVLAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRDRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRTITAKALSEKELVRILKGYMEDAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLALLYDIISAHPLTGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
STARAVIDSVGNSLPPDINESVRDKIFNGVLKTVKKIQLTKK

Download         Length: 1329 bp

>T20845 NC_004459:2039624-2040952 [Vibrio vulnificus CMCP6]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGCACAAACGGCGCACATGTTTT
CACTTACGATTCGGGTTGGGTTTTAGCACCAAATGGTCGTCCTATCTCGCTTTCTATGCCTCTCAGGAAGGATGCGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTACTGCCAGATAATCAGCAGATACGAGATAGAATAGCTGCTCGCTAT
AAAGCAGATACTAAACAGCCATTCGACCTATTAGCTAAGGTTGGTCGAGATGCTGTAGGTGCTATCACGCTAGTTCCAGA
GGGCTTTGATGTAGATGATCATCGAACCATAACCGCAAAGGCGTTATCCGAAAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGACGCTCCTTTGGGGATGCTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTGTTTCACGATGGAAGATGGATGCTACCACAGGGAATGACTCCAACTACGCATATTATCAAGCTGCCAATAGG
TGAAATTGTTTCTCAGAACAATGTTATTGATTTGTCTGCTAGTGTAGATAATGAGTTGATTTGTATGAGGCTAGCAAAGG
CGTTCGGCATTCAAACGGCAAACTGTGACATTATTCGTGCTGGTGATGTTCGTGCCTTGTCTGTTGAGCGATTTGACCGA
AAATTATCTTCTGATAACAGCTATTACTTGCGCTTGCCCCATGAGGATTTTTGCCAGGCAAAAGGGATTCCCTCAGCTAG
AAAATATGAAATTGACGGTGGTATCGGCATAGAAGAATCTATTGATATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACTACTGTATGACATTATCTCGGCACATCCACTGACAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGCACTAGTGGGCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTCGAAGATACCTTTCACACTATGAACGTCCCGAACATAAGGCGAGAAAAGGTTCGCTTATTGCTTGATGAGTTTGAA
TCGACGGCAAGGGCGGTGATTGATTCTGTCGGAAACTCGCTACCACCTGATATTAATGAAAGCGTAAGAGATAAGATATT
TAACGGTGTCTTAAAGACAGTTAAGAAGATTCAATTGACAAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8746.01 Da        Isoelectric Point: 7.2036

>AT20845 WP_011079938.1 NC_004459:2039391-2039630 [Vibrio vulnificus CMCP6]
MLVNTPTVLGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Download         Length: 240 bp

>AT20845 NC_004459:2039391-2039630 [Vibrio vulnificus CMCP6]
ATGCTAGTTAACACACCGACAGTCCTCGGCAATGCGTTACGCGAAGCCCGAAAGGACAATGGCCTAAAGCAAACAGATCT
TGGTCTGCGACAAGCAACAGTATCTAATTTTGAAAGCAACCCTGAAAAATCCACGATAGAAACATTGTTCAAGCTCCTGT
CTATCAATGGACTAGAAATGCATATTGTGCCGAAAGGCAAGCACATTACTGAAACTAAAGGGGCTGTTGACGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References