Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1159889..1160418 Replicon chromosome
Accession NZ_CP077894
Organism Staphylococcus aureus strain 329

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KU540_RS05620 Protein ID WP_000621175.1
Coordinates 1160056..1160418 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KU540_RS05615 Protein ID WP_000948331.1
Coordinates 1159889..1160059 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU540_RS05585 (1154926) 1154926..1155486 + 561 WP_001092421.1 K(+)-transporting ATPase subunit C -
KU540_RS05590 (1155694) 1155694..1156173 + 480 WP_001287076.1 hypothetical protein -
KU540_RS05595 (1156166) 1156166..1157749 + 1584 WP_001294639.1 PH domain-containing protein -
KU540_RS05600 (1157736) 1157736..1158227 + 492 WP_001205909.1 PH domain-containing protein -
KU540_RS05605 (1158231) 1158231..1158590 + 360 WP_000581197.1 holo-ACP synthase -
KU540_RS05610 (1158656) 1158656..1159804 + 1149 WP_001281140.1 alanine racemase -
KU540_RS05615 (1159889) 1159889..1160059 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KU540_RS05620 (1160056) 1160056..1160418 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KU540_RS05625 (1160767) 1160767..1161768 + 1002 WP_000390826.1 PP2C family protein-serine/threonine phosphatase -
KU540_RS05630 (1161887) 1161887..1162213 + 327 WP_001052491.1 anti-sigma factor antagonist -
KU540_RS05635 (1162215) 1162215..1162694 + 480 WP_225805901.1 anti-sigma B factor RsbW -
KU540_RS05640 (1162669) 1162669..1163439 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T208447 WP_000621175.1 NZ_CP077894:1160056-1160418 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T208447 NZ_CP103645:2689104-2689211 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT208447 WP_000948331.1 NZ_CP077894:1159889-1160059 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT208447 NZ_CP103645:c2689057-2688991 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References